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To explore the role of RRM2 in the PI3K/Akt signaling pathway, we examined the expression levels of PI3K pathway-related proteins including Akt, phosphorylated Akt (pAkt), PI3K kinase p85, PI3K kinase p110, and PTEN in TPC-1, RRM2 knockdown ( RRM2 -KD-TPC-1), and RRM2 overexpression ( RRM2 -OE-TPC-1) cells by Western blot
References Hanif M, Nagarajan JS, Murphy R, et al
LR3 IGF-1 is a modified analog of human IGF-1 with a 13-amino acid extension at the N-terminus and a substitution of Arg at position 3, which significantly reduces its affinity for IGF-binding proteins
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