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in the absence of normal gut microbiota in the mouse dams, the expression of BEC claudin-5 and occludin is diminished and an increase in BBB permeability is observed in the offspring (Braniste et al., 2014)
So this is so critical
It is present naturally in every cell of the body, as well as in the blood, the bile and the fluid lining the lungs
Notably, as these studies were largely open-label with varying intensities of lifestyle intervention and control conditions, they are better suited as evidence for strategic feasibility rather than as direct equivalents to placebo-controlled trials
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