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Second, since the Asian patients were all from Japan and China, the representation of Asian subjects was compromised, and subsequent studies should strive to include Central and South Asian patients

This is not a rule, just a pattern observed across thousands of trial participants

Sadiur Rahman Sajon et al

Astrocytes release ApoE-containing exosomes to transport keto bodies, cholesterol, and phospholipids between glia and neurons to supply them with energy