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Potential concerns include effects on angiogenesis that theoretically could influence tumor development or progression, though preclinical studies show context-dependent effects that inhibit pathological angiogenesis in some tumor models
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Both proteins (GLP-1 and VEGFA) share common pathways and most importantly interacts with cytoplasmatic Src kinase that controls a wide variety of signaling pathways leading to control of vessel tone through endothelial cell signaling
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