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This is not a perfect system, but it catches the most visible problems
That reinforces something we have always emphasised: the importance of independent COA testing and knowing exactly what a compound is and where it came from
Mullally and coworkers found genomic islands (GIs) associated with hyperinvasive lineages (absent in cc53), which encode functions that facilitate meningococcal access to different cell types, leading to an increased risk for IMD (Mullally et al., 2021)
Such a change was also found in healthy individuals which showed reduction of DNA methylation in individuals with the TT MTHFR genotype compared to subjects with CC MTHFR 29
