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de Kluiver H, Jansen R, Penninx BWJH, Giltay EJ, Schoevers RA, Milaneschi Y
The review confirmed GLP-1R is expressed at high levels on -cells, where GLP-1 stimulates somatostatin secretion which in turn indirectly suppresses both glucagon and insulin through paracrine mechanisms
Available case reports demonstrate plausibility, but large observational studies are needed to estimate actual risk
The body needs time to adapt to GLP-1 receptor activation, and rushing this process creates unnecessary complications
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