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In the specific context of sleep promotion and nervous system protection, the spotlight turns to endogenous peptides
Chronic activation of GLP-1R further upregulates fibronectin type III domain-containing 5 (FNDC5)/irisin and uncoupling protein 1 (UCP1), supporting the rationale for BAT-targeted polymer-lipid hybrid NPs co-loaded with 3-adrenergic agonists to amplify thermogenic energy expenditure [241]
Muscle Preservation and Metabolic Stress Resistance L-Carnitine demonstrates significant muscle-protective properties through multiple mechanisms including prevention of protein degradation, reduction of inflammatory signaling, and maintenance of mitochondrial integrity during metabolic stress
