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Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision
Despite some label instructions on magnesium products, Meacham says, the calming effects are less to do with whether the stomach is empty, probably not as much as the type of magnesium being consumed
