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Effects on skeletal muscle fibers, amino acid uptake, and protein synthesis IGF-1 LR3 has been shown to have a variety of effects on skeletal muscle fibers, including increased size and number of myofibrils (the contractile units within muscle cells), as well as improved sarcomere organization (the structural units within myofibrils)

Gaps in safety assessment encompass limited long-term data in vulnerable populations, an incomplete understanding of horizontal gene transfer related to antimicrobial resistance, and uncertainty regarding the systemic impact of prolonged microbiome modulation, particularly with next-generation strains lacking a long history of safe use (142)