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You have high baseline BMI where 28.7% weight loss represents a clinically meaningful target

The recommendation is to take NSAIDs with whatever food you do eat, use the lowest effective dose, and consider switching to acetaminophen for pain management where possible

However, side effect severity varies significantly based on factors such as: Individual sensitivity Dosage Rate of dose escalation Dietary habits Existing digestive conditions Both medications are generally introduced gradually to improve tolerability and minimize side effects

Use medications to slow digestion In some cases, lifestyle changes alone might not be enough to resolve diarrhea