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Aim for gradual, sustainable weight loss of 0.51 kg weekly rather than rapid changes
Whilst mild gastrointestinal symptoms are common and often resolve spontaneously, certain symptoms may indicate more serious complications requiring clinical assessment
Safety PRODUCT WARNINGS: KEEP OUT OF REACH OF CHILDREN
This is achieved through stimulation of pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons and the indirect inhibition of the orexigenic neuropeptide Y/agouti-related peptide (NPY/AgRP) axis via GABAergic mechanisms.18 The partial permeability of the bloodbrain barrier in circumventricular structures and the arcuate nucleus, alongside potential GLP-1R-dependent involvement of tanycytes, facilitates the access of both LIRA and SEMA to brain regions that are essential in the regulation of food intake
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