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Despite their critical role, there are relatively few E1-activators compared to the vast array of E3 ligases
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Most trial reported ALT values were also coupled with ALT ULNs higher than 33 U/L, which led to a lower frequency in subject identification on eDISH plots of either Hys Law or Temples Corollary quadrants compared to using a fixed ALT ULN of 33 U/L and TB ULN of 1.25 mg/dL
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