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The success of GLP-1 receptor agoniststherapies that exert both central and peripheral effectshas forced a re-evaluation of this cautionary stance
The remaining 54.1% [95% CI 29.079.3%] of the effect of tirzepatide on UACR appeared to be direct effects of the pooled tirzepatide doses, with unmodeled variables potentially contributing to some extent [96]
JAMA Network Open, 8 (1), e2457349.
2025 marked major milestones in CNS drug development, with multi-billion-dollar partnerships including AbbVie/Gilgamesh, Novartis/Avidity and Roche/Manifold highlighting robust investment across numerous therapeutic areas
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