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used proteomic approaches and identified HSP70 and HSP90 as potential targets mediating the protective effects of baicalin (Hou et al., 2022)
We moved away from IV because intracellular NAD+ levels, which is where the benefit actually happens, do not reliably increase with IV administration
At the concentrations typically found in cosmetic products, systemic absorption through intact skin is considered minimal, and copper toxicity from topical use has not been reported in the published literature
The total level can spike unpredictably
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