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In addition, spermidine has been shown to reduce the accumulation of ROS and enhance the activity of antioxidant enzymes such as SOD and catalase, thereby mitigating oxidative damage at the cellular level (Reference Jeong, Cha and Han21)

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A 2016 study published in Nature Scientific Reports showed GHK-Cu produced no cytotoxicity to human keratinocytes at concentrations up to 5,800 micromolar over 72 hours and did not induce inflammatory biomarkers unlike other copper compounds

Assessing the causal effects of human serum metabolites on 5 major psychiatric disorders