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Saupe M, Rauschenberger L, Preu M, Oswald S, Fussek S, Zimmermann U et al
For the second generation we repeated the process described for the first generation, and from the 50 best sequences for each group, we selected five diverse sequences as parents for the third generation
Among the most promising non-incretin receptor targets are amylin (Amy) receptors (AMYRs), supported by data from phase I and phase II clinical trials showing efficacy of the long-acting amylin and calcitonin receptor agonist, cagrilinitide (Cagri), both as monotherapy 2,3 and in combination with the selective GLP-1R agonist, semaglutide 4,5
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