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Animal model research demonstrated that depleting GSH via inhibition of GCL triggered a cascade of lipid peroxidation and cell death in mesencephalic cultures, identifying oxidative stress from glutathione insufficiency as a likely initiating mechanism in neurodegeneration

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Cagrilintide has a half-life of about 78 days (roughly 159195 hours measured in a Phase 1b study), and tirzepatide about 5 days (approximately 120 hours)