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446 These inhibitors, such as geldanamycin, bind to the N-terminal nucleotide-binding pocket of HSP90 with higher affinity than ATP, leading to the proteasomal degradation of HSP90-dependent client proteins
Standard human dosing protocols based on animal studies suggest 0.25-0.5 mg daily via subcutaneous injection for 4-8 weeks
The wording on this page intentionally avoids instructions, usage guidance, administration language, or outcome-based statements
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