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But cagrilintide works through a completely different hormonal system, and its tolerability profilewhich well cover nextis one of its strongest advantages
Although IFN- suppresses tumor-derived chemokines to inhibit the tumor trafficking of CXCR2 + CD68 + macrophages (associated with M2 polarization) by blocking the CXCL8-CXCR2 axis, thereby counteracting immunosuppression and overcoming therapeutic resistance, dysregulated IFN signaling can promote M2-skewed macrophage polarization, which compromises the efficacy of anti-PD-1/PD-L1 therapies [299]
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