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The EMA's European Public Assessment Report (EPAR) for Rybelsus indicates that deviations from the prescribed administration protocolsuch as taking the medication with food or insufficient waiting timecan significantly reduce absorption
The clinical significance of these interactions will be detailed in the prescribing information when orforglipron is approved, and is an important consideration for the many patients with obesity or type 2 diabetes who take multiple concurrent medications
Staying hydrated, eating adequate soluble fiber, and maintaining gentle physical activity help reduce constipation risk
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