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Akkermansia Muciniphila: A New Approach to Metabolic Disorders Examining the use of Akkermansia muciniphila as a promising mitigation for metabolic disorders Aava Joshi, Dan Li, MD, PhD Aava Joshi
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Controls received vehicle only, BSO-only group received 125 mg/kg twice daily on days 1, 2 and 3 via intraperitoneal injection, L-PAM-only group received 10 mg/kg dose on days 2 and 3 given intravenously into the lateral tail vein, and the L-PAM+BSO group received both drugs as per above
(2) Cardiac remodeling: COX-2 expression is increased in conditions such as myocardial infarction and HF, leading to increased cardiac remodeling and functional decline
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