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GLP-1 RAs regulate immune cell signaling, suppress proinflammatory cytokines (including tumor necrosis factor alpha (TNF), interleukin-6 (IL-6), and interleukin-1 beta (IL-1)), enhance anti-inflammatory cytokines (interleukin-10- (IL-10)), and decrease reactive oxygen species
doi: 10.1016/j.neurobiolaging.2012.04.009 8 SinghNKSinghAVarshneyMAgrawalR
Tramadol works in the central nervous system (CNS) to change how your body perceives and responds to pain
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