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In a two-year randomised, placebo-controlled trial in adults aged 60 to 81, fat-free mass rose by 1.1 kg while the placebo group lost 0.5 kg but the added lean mass did not produce measurable gains in strength or physical function, and fasting blood glucose rose while insulin sensitivity fell (Nass et al., Annals of Internal Medicine , 2008)
A patient with compulsive eating tendencies often does better on Contrave because of the reward-pathway component
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In addition, carnitine metabolism and production in the body may be enhanced with supplemental lysine and methionine
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