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To prevent evidence updates from lagging behind clinical practice, this review proposes a Learning Health System (LHS) objective: iteratively updating risk stratification and decision support through continuous real-world data streams rather than relying on static conclusions

This development represents a significant step forward in expanding treatment options for patients seeking evidence-based medical weight management support particularly for those who may have a needle phobia or prefer a non-injectable approach

For example, exploratory analyses from AMPLITUDE-O found no statistically significant interaction between efpeglenatide treatment effect and background SGLT2 inhibitor use for cardiovascular or HF outcomes [25]

p = 0.13) to 0.35 (95% CI: 0.180.52