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Sinnema M, Maaskant MA, van Schrojenstein Lantman-de Valk HMJ, van Nieuwpoort IC, Drent ML, Curfs LMG, et al

Even a very mild state of dehydrationas little as 1% to 2% fluid losscan significantly impair your energy levels, reduce your ability to concentrate, and cause persistent headaches

The significant increase in fissures observed in the PCPA-induced insomnia model group suggests that sleep disturbances may lead to notable changes in brain tissue morphology (Figures 8A,B)