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As a comparison, the ECL1 of GIPR partially unwound with the presence of three proline residues (P195 ECL1 , P197 ECL1 and P199 ECL1 ), resulting in reduced interactions between ECL1 and tirzepatide compared to that in GLP-1R (Fig

However, there are also oral versions (pills) that deliver similar types of medication through the digestive system

and Zepbound (tirzepatide), which was approved in 2023 (it was previously available to treat diabetes under the brand name Mounjaro)

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