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Less than 10% of the total dose is excreted in the urine as parent and metabolites over 108 hours
Some of the diagnostic and clinical work exists in non-English literature or specific national contexts, complicating a complete synthesis
GLP-1 is one of the gut hormones that profoundly affects glucose regulation by promoting post-prandial insulin secretion, and GLP-1 based drugs are approved for the treatment of T2D (74)
The primary actions of GLP-1 include stimulating insulin secretion from pancreatic beta cells in response to elevated blood glucose (importantly, this insulin release is glucose-dependent, reducing hypoglycaemia risk), suppressing glucagon release (which prevents the liver from producing excess glucose), and slowing gastric emptying
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