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Discontinuation rates due to adverse events were reported as low and single-digit across both REDEFINE 1 and 2, which Novo Nordisk highlighted as a positive tolerability signal given the drugs dual-mechanism approach
Their thyroid medication doses may need adjustment as weight changes, but the medications are compatible
Temperature requirements Refrigerated storage (2 to 8 degrees Celsius / 35.6 to 46.4 degrees Fahrenheit): The solution remains stable and potent for 28 days
The tirzepatide meal plan and dietary strategies can further improve tolerability
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