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While some polyphenol-rich extracts, such as grape seed extract, have shown high tolerability in animal and short-term human studies, the safety of long-term, high-dose intake across a broad population spectrum remains to be confirmed (122, 123)
Despite its known effects, the physiological role of DSIP remains unclear, partly due to the lack of identification of its gene and receptor
Currently, its neuroprotective effects on neurodegenerative diseases such as AD and PD have been widely studied
In studies observing elderly adults suffering from profound mental and physical exhaustion, high doses of ALCAR (up to 4 grams per day) significantly reduced both mental and physical fatigue while improving everyday functional capacity
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