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To test the local effects of GLP-1(736) and exendin 939 on heat sensitivity, PWL was measured via the Hargreaves radiant heat apparatus following intraplantar administration of 10 g of GLP-1(736) or vehicle (0.9% saline) ( n = 5 per group) in a volume of 10 L
These same pharmacology properties direct receptor activation, reduced binding-protein clearance, and the long half-life explain both the anabolic interest researchers have in IGF-1 LR3 and its primary safety liabilities
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