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Mitochondrial dysfunction increases ROS production and creates a vicious cycle that exacerbates neuronal injury (Brown et al., 2005)
Participants received daily injections of either Liraglutide (3mg) or a placebo for 56 weeks
The mitochondrial oxygen consumption rate (OCR) in the presence of the complex I (CI)-linked substrate pyruvate was increased during the darkactive period (ZT14) compared with the light/inactive period (ZT2) (Fig
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