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The sedating effects are cumulative and can persist for 8-12 hours after dosing, making driving or operating machinery dangerous during initial treatment phases
In addition, some aspects of GLP-1 beyond weight loss, such as preclinical evidence on GLP-1 effects in directly modulating the hypothalamuspituitarygonadal axis, or the effects of GLP-1RA on clinical and biochemical expression of hyperandrogenism, still deserve a greater insight, especially in light of a possible therapeutic use in PCOS women independently of obesity
By combining both actions, tirzepatide in Mounjaro gives a stronger effect on weight loss and blood sugar control than treatments that use GLP-1 alone
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