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The Dual-Pathway Model vs Single-Agent Administration The combinations pharmacological rationale mirrors the bodys natural dual-regulation of GH secretion, where both GHRH and ghrelin signals converge on pituitary somatotrophs for optimal GH output
G., Melis, A., Piga, M., Marchionni, A., and Calvani, M
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PC=Placebo An RCT of nondiabetic patients (N = 1961)1: After 68 weeks, mean weight loss was 15% (15 kg) versus 2% (3 kg) PC
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