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Results The disruption of D2R-DAT stimulates locomotor activity As aforementioned, we developed an interfering peptide (TAT-DAT NT ) to disrupt the interaction between DAT and D2R, which can increase locomotor activity in mice [25]

In clinical trials of sermorelin in GH-deficient adults, IGF-1 levels increased significantly with nightly subcutaneous dosing over weeks to months

Looking further ahead, researchers are focusing on developing GLP-1 drugs specifically engineered to better penetrate the central nervous system

Data Availability Data sharing is not applicable to this article as no datasets were generated or analysed during the current study