glp 1 and insurance coverage just changed for as many as 56 million Americans when it comes to the popular GLP-1 medications used to promote weight loss. https://www.wkrg.com/news/glp-1-insurance-change-impacts-millions-of-americans-what-to-know-how-to-tell-if Insurance Coverage for Weight Loss

The administration of liraglutide significantly attenuated PCOS-associated ovarian MGCs apoptosis in a concentration-dependent manner, and these effects were associated to modifications of the phosphorylation sites of forkhead box protein O1 (FoxO1), a negative regulator of cell survival

Cell 167:843857

Preclinical and clinical studies have demonstrated that GLP-1RAs reduce both alcohol craving and intake, confirming the direct neurobiological pathway targeted by this drug class (Farokhnia et al., 2025

Thus the evidence would suggest that although overweight may reduce mortality risk, obesity clearly and incrementally increases mortality risk (vs