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For patients with diabetic kidney disease, this combination may offer complementary renoprotection, though additive effects require further study
The 1998 Johansen pharmacokinetic paper characterised plasma half-life and absorption kinetics (PMID 9879640)
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[2] While metformin has shown modest benefit in preventing progression to diabetes in the Diabetes Prevention Program, using tirzepatide specifically to treat prediabetes would be considered off-label and requires careful clinical judgment and shared decision-making
