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International Journal of Clinical Nutrition & Dietetics
In rare cases, they may lead to more serious reactions, including pancreatitis, gallbladder issues, kidney problems, or severe gastrointestinal symptoms
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A critical reassessment of historical failures reveals that many appetite-related peptide programs were abandoned not because their biology was flawed, but because early development conflated dose-dependent adverse effects or behavioral complexity with intrinsic target unsuitability ( The GLP-1 experience provides an instructive counterexample
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