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Compared with the overnight pre-dose fasting period employed in the reference arm (night30 min), shorter pre-dose fasting periods of 2, 4, and 6 h in the 2 h30 min, 4 h30 min, and 6 h30 min treatment arms resulted in significantly lower semaglutide AUC 024h and C max on Day 10 (estimated treatment ratio ranges: 0.120.43 and 0.120.44, respectively

However, dehydration from the medication can lead to temporary changes in kidney function markers

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