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The Long R3 designation describes two structural changes

Researchers reported a significant increase in the frequency of myeloid dendritic cells, which was also correlated with abnormal right and left amygdala enlargement, severity of GI symptoms, and increased repetitive behaviors

In a 16-week randomized study of 30 obese men with functional hypogonadism who had responded poorly to lifestyle measures, liraglutide raised total testosterone by an average of 2.6 nmol/L and significantly increased LH and FSH a pattern suggesting the HPT axis itself recovered rather than testosterone simply being replaced (Jensterle et al., 2019, Endocrine Connections )

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