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Contrave is a medication that acts to alter [the] brain signal (dopamine pathway) in the part of the brain (hypothalamus) responsible for controlling how hungry we feel and how much energy we burn, as well as in the part of the brain (mesolimbic system) that controls how much pleasure we feel while eating certain foods and how compulsive we feel in repeatedly seeking the same pleasure, Muzamil Hussain, PhD, a clinical research fellow diabetes and obesity at Ulster University in the United Kingdom, and co-author of this study, told Medical News Today

The intestinal barrier and its permeability play an important role in the pathogenesis of obesity and T2D, however, it is still unclear whether increased intestinal permeability is a cause or consequence of metabolic disease, or perhaps both ( 4.1 Chemical Barrier Antimicrobial molecules produced by the intestinal epithelium are important defense mechanisms to prevent infection and dysbiosis of commensal microbiota

doi: 10.1136/gutjnl-2015-310572 73 LinnebjergHKotharePAParkSMaceKReddySMitchellMet al

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