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Selective Anti-Inflammatory Action
(2002) Moderate iron overload enhances lipid peroxidation in livers of rats but does not affect NF-B activation induced by the peroxisome proliferator, Wy-14,643. J Nutri 132: 2525-2531
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These signals activate the NLRP3 inflammasome, which in turn prompts caspase-1 to cleave the inactive pro-IL-1 into the highly biologically active mature IL-1, which is then released extracellularly (99)
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