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Endoscopy, where the procedure is performed entirely through the mouth and esophagus, is indicated in a small subset of patients and typically leads to durable weight loss similar to that of gastric bypass
In this context, using a previously reported -helical peptide as a template sequence (Behera et al., 2022), this study discusses the rational computational design and in silico evaluation of an -helical peptide (SR18: 18 aa) as a potent agonist of GLP-1R, with native GLP-1 and Semaglutide serving as references
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