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Disadvantages to insulin pumps include a potentially high cost compared with insulin shots, the risk of diabetic ketoacidosis (DKA) if the tube is displaced or damaged, the risk of infection at the site of entry and the potentially bothersome necessity of carrying the pump at all times
Once stabilized, HIF-1 translocates to the nucleus and binds hypoxia response elements (HREs) in the promoter regions of key metabolic genes
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