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Therefore, it is most important to develop effective neuroprotective therapies that are able to slow the progression of the disease and extend the lives of patients
doi: 10.1001/jamanetworkopen.2024.27258, 57
Because MC1R is primarily involved in pigmentation biology, tanning response, and related skin signaling, this genotype is most informative for the pigment-related branch of the Melanotan II pathway rather than the central neuroendocrine receptors more directly involved in sexual-function signaling
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