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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )
IL-1 markedly decreased (p 0.003) PPAR mRNA expression
Hagen TM, Wierzbicka GT, Sillau AH, Bowman BB, Jones DP
Abbreviated New Drug is also known as Generic drug and applications are not required to include preclinical (animal) and clinical (human) data to establish safety and effectiveness since the innovator drug has proved its safety and effectiveness
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