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Finally, long-term safety follow-up (12 months) is essential to assess risks of chronic Nrf2 activation (e.g., cancer progression) or antioxidant interference with physiological ROS signaling, highlighted by the bardoxolone methyl experience in diabetic kidney disease (Nangaku et al., 2020)
16, 297304.10.1016/j.jnutbio.2004.09.007 30 OzH
Could FOXO4-DRI affect stem cells or other non-senescent cells
Oleaphen, for example, produces an ultra-high polyphenol olive oil with laboratory-verified total polyphenol content exceeding 2,000 mg/kg -- with hydroxytyrosol and oleocanthal as key active compounds
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