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SURMOUNT-5 was a 72-week, open-label, Phase 3b randomised trial of 751 adults with obesity but without diabetes, comparing maximum-tolerated tirzepatide (10 or 15 mg) against maximum-tolerated semaglutide (1.7 or 2.4 mg)
60 Capsules: 60-day supply at 1 capsule per day
Some protocols slowly increase the dosage over a week to reach 1 mg per day or less, depending on goals and side effects
Both drug classes are recognised in NICE guidance for type 2 diabetes management, though careful monitoring and patient education regarding side effects are essential
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