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Recognized adverse effects include cholelithiasis, gastrointestinal disturbances, and reductions in lean mass [10,11,12]
Patients with a history of pancreatitis should use extreme caution
An earlier study in the New England Journal of Medicine (Wang et al., 2011) made similar observations in relation to dietary choline and phosphatidylcholine
Due to their weekly dosing schedule and greater mean weight loss seen in trials (15% for semaglutide and 21% for tirzepatide, compared to 8% with liraglutide), semaglutide and tirzepatide are more frequently prescribed than liraglutide for treatment of obesity [33,34,35]
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