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If future trials confirm these findings, GLP-1 drugs could soon be at the forefront of migraine management, bringing much-needed hope to millions battling this chronic condition.

GLP-1 drugs now address both conditions simultaneously, making them the treatment of choice across a wide clinical spectrum

Based on our data, we propose that T3 has a regulatory role in insulin-controlled glucose metabolism, and T3 exerts this function by increasing non-12-OH FXR-antagonistic BA levels via downregulating the expression of CYP8B1, which potentiates GLP-1 production via suppressing the intestinal FXR signaling

In addition to clinical evidence, various experiments have confirmed that this drug has anti-arrhythmia, inhibition of platelet aggregation, reversal of myocardial ischemia, improvement of microcirculation and other effects (56, 57)