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A 2024 study in Brain, Behavior, & Immunity - Health identified severe CD8 T-cell dysfunction in both ME/CFS and Long COVID patients, linking this immune exhaustion directly to mitochondrial failure
MOTSc (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded by mitochondrial DNA (mtDNA), not nuclear DNA like most hormones and peptides
This is a fundamentally different approach than PDE5 inhibitors (Viagra, Cialis), which only increase blood flow without affecting desire
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